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We Should Not Accept Scientific Results That Have Not Been Repeated

We Should Not Accept Scientific Results That Have Not Been Repeated

The inconvenient truth is that scientists can achieve fame and advance their careers through accomplishments that do not prioritize the quality of their work.

Why Most Clinical Research Is Not Useful

Why Most Clinical Research Is Not Useful

John Ioannidis argues that problem base, context placement, information gain, pragmatism, patient centeredness, value for money, feasibility, and transparency define useful clinical research. He suggests most clinical research is not useful and reform is overdue.

Reproducibility: Archive computer code with raw data

Reproducibility: Archive computer code with raw data

Software tools such as knitr and R Markdown allow the description and code of a statistical analysis to be combined into a single document, providing a pipeline from the raw data to the final results and figures. Outputs are updated by re-running the scripts using version-control tools such as Git and GitHub.

Patent Law's Reproducibility Paradox

Patent Law's Reproducibility Paradox

Many recent clinical and preclinical studies appear to be irreproducible; their results cannot be verified by outside researchers. This is problematic for not only scientific reasons but legal ones: patents grounded in irreproducible research appear to fail their constitutional bargain of property rights in exchange for working disclosures of inventions.

How should we treat science’s growing pains?

How should we treat science’s growing pains?

Jerome Ravetz has been one of the UK’s foremost philosophers of science for more than 50 years. Here, he reflects on the troubles facing contemporary science. He argues that the roots of science’s crisis have been ignored for too long. Quality control has failed to keep pace with the growth of science.

What does research reproducibility mean?

What does research reproducibility mean?

The language and conceptual framework of “research reproducibility” are nonstandard and unsettled across the sciences. In this Perspective, we review an array of explicit and implicit definitions of reproducibility and related terminology, and discuss how to avoid potential misunderstandings when these terms are used as a surrogate for “truth.”

Most scientists believe there is a crisis in reproducibility

Most scientists believe there is a crisis in reproducibility

Placing trust in science can be easier when findings are confirmed, but a new survey finds that most scientists believe there is a reproducibility "crisis."

John Oliver exposes how the media turns scientific studies into 'morning show gossip'

John Oliver exposes how the media turns scientific studies into 'morning show gossip'

Science "deserves better than to be twisted out of proportion and turned into morning show gossip."

For science to improve, let’s put the right incentives on offer

For science to improve, let’s put the right incentives on offer

The current incentives structure — mostly based on publishing in prestigious journals — discourages sharing, replication, and, some argue, careful science.

Call for papers: publish your confirmatory and non-confirmatory results

Call for papers: publish your confirmatory and non-confirmatory results

In response to rising concerns about irreproducible science and the lack of somewhere to openly discuss these issues, we recently launched the Preclinical Reproducibility and Robustness Channel.